The pathophysiology of circulatory hypertension is complicated. So there are several agents that together have a genetic basis. Experts confirm that through the renin-angiotensin-aldosterone system (SRAA) the one that is most important. Learn about the pathophysiology of high blood pressure
For example, the production of endothelin, the withdrawal of nitric oxide or prostacyclin. As well as the effects of catecholamines or vasopressin, of the ouabain-sensitive factor or FDE, of thromboxane A2 (TxA2). In addition to different endogenous vasopressor components.
Learn about the pathophysiology of high blood pressure
In relation to blood pressure pathologies are the renin-angiotensin-aldosterone systems.
For its part, renin is a peptide catalyst of the aspartyl protease family, with a PM of 37,000 to 40,000. So it can emerge to the circulation in an immune or indulged way as renin, absorbed in a systematized way.
The first production, from angiotensinogen or renin substance is angiotensin I. Angiotensin crystallizes in the octapeptide angiotensin II. But an angiotensin 1-7 and vasodepressant action can also be established.
In people, AIII accounts for 15 to 30% of the activity of the AII.
The vast majority of essential hypertensive patients have different forms of tension. And that is why the circulation stops acting normally on the vasomotor tone. Pathophysiology blood pressure
The physiology of arterial hypertension can be related to minute heart volumes. In addition peripheral resistance, renin-angiotensin-aldosterone and central nervous system. In addition to bradykinin, endothelin, nitric oxide among other components.
The maintenance of arterial hypertension is due to the balance between the minute heart volume and peripheral vascular resistance. So it is represented by small gauge roads that have smooth muscle.
Most patients with high blood pressure have a normal minute volume but high peripheral resistance. Learn about the pathophysiology of high blood pressure. Always remember to have a medical check-up to prevent and not suffer from blood pressure.